منابع مشابه
JAKs, Stats, and CK2?
derivatives suppress TH17 cell differentiation by antagonizing RORgammat activity. Activating mutations in JAK2, a tyrosine kinase that serves as a critical signaling protein for multiple cytokines, are associated with BCR-ABL1–negative myelo-proliferative neoplasms. In this issue of Blood, Zheng and colleagues report that the constitutively activated kinase CK2 binds to JAK2 and is required fo...
متن کاملJAKs and STATs in chemoresistance
Many cancer patients develop resistance to chemotherapeutic drugs and this results in elevated mortality. Understanding the mechanisms that mediate drug resistance is critical to develop novel therapeutic strategies. Fibroblast growth factor (FGF)-2, which leads to the formation of a B-RAF/PKCε/S6K2 multi-protein complex, plays a key role in chemoresistance. This enhances the selective translat...
متن کاملJaks, STATs, Cytokines, and Sepsis.
Sepsis remains a significant cause of morbidity and mortality in the intensive care unit (68), affecting more than 500,000 patients per year in the United States (39). The incidence is increasing despite the major advances in the development of antimicrobial agents and other supportive treatments (56). Septic patients often succumb to a systemic inflammatory response, of which multiple organ fa...
متن کاملJaks and stats as therapeutic targets.
Cytokines have critical functions in regulating immune responses. A large number of these factors bind related receptors termed the Type I and Type II families of cytokine receptors. These receptors activate Janus kinases (Jaks) and Stat family of transcription factors. The essential and specific function of Jaks and Stats is particularly well illustrated by human and mouse mutations. The possi...
متن کاملSignaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency.
Cytokines that bind to the interleukin-2 (IL-2) receptor common gamma chain (gamma c), including IL-2, IL-4, IL-7, IL-9, and IL-15, are important for the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes. These cytokines have overlapping biological effects that in part result from the use of the shared receptor subunit gamma c. Recently it has b...
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ژورنال
عنوان ژورنال: Annual Review of Immunology
سال: 1998
ISSN: 0732-0582,1545-3278
DOI: 10.1146/annurev.immunol.16.1.293